Patent Number: 10,028,962

Title: 2-amino-6-methy1-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl-1,- 3-thiazol-4-yl amides

Abstract: The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, ##STR00001## and the variable R.sup.1 is as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Inventors: Brodney; Michael Aaron (Newton, MA), Beck; Elizabeth Mary (Oxford, GB), Butler; Christopher Ryan (Canton, MA), Zhang; Lei (Auburndale, MA), O'Neill; Brian Thomas (Haddam, CT), Barreiro; Gabriela (Sao Paulo, BR), LaChapelle; Erik Alphie (Uncasville, CT), Rogers; Bruce Nelsen (Belmont, MA)

Assignee: Pfizer Inc.

International Classification: C07D 519/00 (20060101); C07D 513/04 (20060101); A61K 31/542 (20060101)

Expiration Date: 2022-07-24 0:00:00