Patent Number: 10,030,024

Title: Imidazopyridazines useful as inhibitors of the PAR-2 signaling pathway

Abstract: The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: ##STR00001## wherein the variables are as defined herein.

Inventors: Farmer; Luc J. (Montreal, CA), Fournier; Pierre-Andre (Vaudreuil-Dorion, CA), Lessard; Stephanie (St-Jean-sur-Richelieu, CA), Liu; Bingcan (Montreal, CA), St-Onge; Miguel (Vaudreuil-Dorion, CA), Sturino; Claudio (Ile Bizard, CA), Szychowski; Janek (Montreal, CA), Yannopoulos; Constantin (Notre-Dame de I'lle Perrot, CA), Vallee; Frederic (Montreal, CA), Lacoste; Jean-Eric (Laval, CA), Martel; Julien (Montreal, CA), Bubenik; Monica (Mascouche, CA), Ramtohul; Yeeman (Pierrefonds, CA), Sayegh; Camil Elie (Dorval, CA)

Assignee: Vertex Pharmaceuticals Incorporated

International Classification: C07D 487/04 (20060101); C07D 519/00 (20060101)

Expiration Date: 2022-07-24 0:00:00