Patent Number: 10,030,044

Title: Nucleotides for the treatment of liver cancer

Abstract: Provided herein are compounds, compositions and methods for the treatment of liver cancer such as hepatocellular carcinoma, cholangiocarcinoma, or biliary tract cancer. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-cancer agents. In certain embodiments, the compounds are nucleoside analogs of Formula I: (I); or a pharmaceutically acceptable salt thereof, wherein Base, Z.sup.1, Z.sup.2, Z.sup.3, Z.sup.4, V, W, X, Ar, R.sup.1 and R.sup.2 are as described herein. ##STR00001##

Inventors: Dousson; Cyril B. (Canet, FR), Dukhan; David (Saint Gely du Fesc, FR), Parsy; Christophe Claude (Jacou, FR)


International Classification: A01N 43/04 (20060101); C07H 19/20 (20060101); C07H 19/16 (20060101); C07H 19/06 (20060101); C07H 19/10 (20060101); C07H 19/207 (20060101); A61K 31/70 (20060101); A61K 31/7076 (20060101); A61K 31/7052 (20060101); A61K 31/706 (20060101); A61K 31/7068 (20060101); A61K 31/7072 (20060101); A61K 31/708 (20060101); A61K 31/7064 (20060101)

Expiration Date: 2022-07-24 0:00:00