Patent Number: 6,165,445

Title: Pharmaceutical compositions containing alkylaryl polyether alcohol polymer

Abstract: There is provided novel pharmaceutical compositions containing tyloxapol as the active ingredient. These formulations comprise tyloxapol at concentrations above 0.125%, preferably from about 0.25% to about 5.0%. In addition, the invention encompasses pharmaceutical compositions having reduced hypertonicity which compositions comprise tyloxapol in pharmaceutically acceptable solutions without significant concentrations of hypertonic agents or other active ingredients NaHCO.sub.3, or active phospholipids, such as DPPC. The less hypertonic formulations allow one to derive all the benefits of the active ingredient tyloxapol, such as its reduced toxicity and enhanced half-life, while avoiding or reducing side effects, such as bronchospasms, associated with the various hypertonic agents or other active ingredient agents.

Inventors: Kennedy; Thomas P. (Richmond, VA)

Assignee: Charlotte-Mecklenburg Hospital Authority

International Classification: A61K 31/74 (20060101); A61K 31/765 (20060101); A61K 9/12 (20060101); A61K 009/12 (); A61K 031/765 ()

Expiration Date: 12/26/2013