Patent Number: 6,165,461

Title: Tao protein kinases and methods of use therefor

Abstract: Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

Inventors: Cobb; Melanie (Dallas, TX), Hutchison; Michele (Dallas, TX), Chen; Zhu (Dallas, TX), Berman; Kevin (Dallas, TX)

Assignee: Board of Regents, University of Texas System

International Classification: C12N 9/12 (20060101); A61K 38/00 (20060101); A61K 038/51 (); C12N 009/12 ()

Expiration Date: 12/26/2013