Patent Number: 6,165,464

Title: Monoclonal antibodies directed to the HER2 receptor

Abstract: A method of inhibiting growth of tumor cells which overexpress a growth factor receptor or growth factor by treatment of the cells with antibodies which inhibit the growth factor receptor function, is disclosed. A method of treating tumor cells with antibodies which inhibit growth factor receptor function, and with cytotoxic factor(s) such as tumor necrosis factor, is also disclosed. By inhibiting growth factor receptor functions tumor cells are rendered more susceptible to cytotoxic factors.

Inventors: Hudziak; Robert M. (Corvallis, OR), Shepard; H. Michael (Rancho Santa Fe, CA), Ullrich; Axel (Portola Valley, CA), Fendly; Brian M. (Half Moon Bay, CA)

Assignee: Genetech, Inc.

International Classification: A61K 47/48 (20060101); C07K 16/32 (20060101); C07K 16/18 (20060101); A61K 039/395 (); C07K 016/00 (); C07K 016/28 (); C07K 016/30 (); C12N 005/12 ()

Expiration Date: 12/26/2017