Patent Number: 6,165,470

Title: Albumin derivatives with therapeutic functions

Abstract: Utilization of albumin as a stable plasma transporter with a therapeutic function that is derived from a membrane receptor. The present invention is exemplified by the description of new therapeutic agents that can be used in the treatment of Acquired Immunodeficiency Syndrome: hybrid macromolecules composed of albumin derivatives coupled to derivatives of the CD4 receptor having a normal or a higher affinity for the HIV-1 virus.

Inventors: Becquart; Jerome (Paris, FR), Fleer; Reinhard (Gif sur Yvette, FR), Hirel; Philippe (Paris, FR), Klatzmann; David (Paris, FR), Landais; Didier (Paris, FR), Mayaux; Jean-Fran.cedilla.ois (Fontenay aux Roses, FR), Yeh; Patrice (Paris, FR)

Assignee: Rhone-Poulenc

International Classification: C07K 14/435 (20060101); C12N 15/62 (20060101); C12N 15/67 (20060101); C12N 15/81 (20060101); C07K 14/00 (20060101); C07K 14/47 (20060101); C07K 14/82 (20060101); C07K 14/765 (20060101); C07K 14/73 (20060101); A61K 38/00 (20060101); A61K 039/00 (); A61K 039/21 (); C12P 021/04 (); C07K 014/00 ()

Expiration Date: 12/26/2013