Patent Number: 6,165,471

Title: Homogeneous human papillomavirus capsomere containing compositions, methods for manufacture, and use thereof as diagnostic, prophylactic or therapeutic agents

Abstract: The present invention relates to stable HPV capsomeres which express at least one virus-neutralizing conformational epitope of a native HPV L1 protein which are substantially incapable of assembly into virus-like particles. These capsomeres, because of their smaller size, and immunogenic properties are well suited for use in HPV vaccines and as diagnostic agents. Moreover, because of their smaller size (relative to VLPs), these stable capsomeres may be easily purified and should result in HPV vaccines of enhanced homogeneity.

Inventors: Garcea; Robert L. (Boulder, CO), Suzich; JoAnn A. (Washington Grove, MD), McCarthy; Michael P. (Poolesville, MD), Rose; Robert C. (Dansville, NY)

Assignee: University of Colorado, University Technology Corporation

International Classification: A61K 39/12 (20060101); C07K 14/005 (20060101); C07K 14/025 (20060101); A61K 39/00 (20060101); A61K 039/12 ()

Expiration Date: 12/26/2017