Patent Number: 6,165,478

Title: DNA encoding Chlamydia pneumoniae antigenic polypeptide

Abstract: Chlamydia pneumoniae antigenic polypeptides, which comprise polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1; DNAs encoding said antigenic polypeptides, or DNAs complementary thereto; recombinant vectors carrying said DNAs; transformants containing said recombinant vectors; a method for production of an anti-Chlamydia pneumoniae antibody, wherein the antigenic polypeptide is used as an antigen; fused proteins of an antigenic polypeptide of Chlamydia pneumoniae with dihydrofolate reductase, in which polypeptide A containing a sequence of at least 5 consecutive amino acids in the polypeptide of SEQ ID NO: 1 is bound to the polypeptide of SEQ ID NO: 14 either directly or via an intervening amino acid or amino acid sequence; DNAs encoding the fused proteins, or DNAs complementary thereto; recombinant vectors carrying the DNAs; transformants containing said recombinant vectors; a method for production of an anti-Chlamydia pneumoniae antibody; probes and primers for detection and/or measurement of Chlamydia pneumoniae gene; a method for detection and/or measurement of Chlamydia pneumoniae gene, wherein the probe or primer is used; reagents for detection and/or measurement of Chlamydia pneumoniae gene, which comprise the probe or primer; and agents for diagnosis of Chlamydia pneumoniae infections, which comprise the probe or primer as an active ingredient.

Inventors: Izutsu; Hiroshi (Ibaraki, JP), Obara; Kazuhiko (Ibaraki, JP), Matsumoto; Akira (Okayama, JP)

Assignee: Hitachi Chemical Company, Ltd.

International Classification: C07K 14/195 (20060101); C07K 14/295 (20060101); C12N 9/06 (20060101); A61K 38/00 (20060101); A61K 39/00 (20060101); A61K 039/118 ()

Expiration Date: 12/26/2013