Patent Number: 6,165,488

Title: Adhesive composition with macromolecular polyaldehyde base and method for cross-linking collagen

Abstract: A biocompatible, bioresorbable and nontoxic adhesive composition for surgical and/or therapeutic use, especially for the bonding of biological tissues to one another or to an implanted biomaterial, is provided which comprises at least one biodegradable macromolecular polyaldehyde of natural origin in aqueous solution and a collagen-based component dissolved in aqueous medium. A process for preparing this composition is also provided wherein these aqueous components are mixed together (e.g., at neutral, physiological pH) to give a gel which is rapidly applied to tissues and/or biomaterial to achieve binding. The present invention is advantageous in that it provides biodegradable macromolecular polyaldehydes with adhesive properties and the ability to be extremely well tolerated by the recipient while retaining their adhesive properties during their retention in the body. The invention thus makes it possible to rapidly bind biological tissues to one another or to implanted biological material without tissue lesions in a manner which also retains the quality and the mechanical strength of the adhesion.

Inventors: Tardy; Michel (Lyons, FR), Volckmann; Herve (Lyons, FR), Tiollier; Jerome (Lyons, FR), Gravagna; Philippe (Irigny, FR), Tayot; Jean-Louis (La Tour de Salvagny, FR)

Assignee: Societe Anonyme de Developpement des Utilisations du Collagene S.A.D.U.C.

International Classification: A61L 24/04 (20060101); A61L 24/00 (20060101); A61L 24/08 (20060101); C09J 189/00 (20060101); C08H 1/06 (20060101); C09J 189/06 (20060101); C08H 1/00 (20060101); A61F 002/02 ()

Expiration Date: 12/26/2017