Patent Number: 6,165,508

Title: Controlled release of metal cation-stabilized interferon

Abstract: This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation-stabilized interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.

Inventors: Tracy; Mark A. (Arlington, MA), Bernstein; Howard (Cambridge, MA), Khan; M. Amin (Downington, PA)

Assignee: Alkermes Controlled Therapeutics, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/56 (20060101); A61K 9/16 (20060101); A61K 38/21 (20060101); A61K 009/10 ()

Expiration Date: 12/26/2013