Patent Number: 6,165,713

Title: Composition and methods relating to DNA mismatch repair genes

Abstract: Genomic sequences of human mismatch repair genes are described, as are methods of detecting mutations and/or polymorphisms in those genes. Also described are methods of diagnosing cancer susceptibility in a subject, and methods of identifying and classifying mismatch-repair-defective tumors. In particular, sequences and methods relating to human mutL homologs, hMLH1 and hPMS1 genes are provided.

Inventors: Liskay; Robert M. (Lake Oswego, OR), Bronner; C. Eric (Portland, OR), Baker; Sean M. (Portland, OR), Bollag; Roni J. (Martinez, GA), Kolodner; Richard D. (Jamaica Plain, MA)

Assignee: Oregon Health Sciences University

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C12Q 1/68 (20060101); C12Q 001/68 (); C07H 021/04 (); C12P 019/34 ()

Expiration Date: 12/26/2017