Patent Number: 6,165,720

Title: Chemical modification of DNA using peptide nucleic acid conjugates

Abstract: Complexes comprising a nucleic acid molecule and a conjugated peptide nucleic acid (PNA). The PNA may be labeled or conjugated to a protein, peptide, carbohydrate moiety or receptor ligand. These complexes are used to transfect cells to monitoring plasmid biodistribution, promote nuclear localization, induce transcriptional activation, lyse the endosomal compartment and facilitate transfection. These complexes increase the efficiency of expression of a particular gene.

Inventors: Felgner; Philip L. (Rancho Santa Fe, CA), Zelphati; Olivier (La Jolla, CA), Bennett; C. Frank (Carlsbad, CA)

Assignee: Gene Therapy Systems

International Classification: A61K 48/00 (20060101); C07K 14/035 (20060101); C07K 14/005 (20060101); C07K 14/00 (20060101); C12N 15/67 (20060101); C12N 15/65 (20060101); C12Q 001/64 (); C12N 015/63 (); C07H 021/00 ()

Expiration Date: 12/26/2017