Patent Number: 6,165,738

Title: Expression in yeast of antigenically active, recombinant hybrid glutamic acid decarboxylase

Abstract: An antigenically active hybrid glutamic acid decarboxylase (GAD) comprising an amino-terminal moiety derived from the GAD67 isoform linked directly or indirectly with a middle and carboxy-terminal moiety derived from the GAD65 isoform, and production thereof as a recombinant protein by expression in eukaryotic host cells, particularly yeasts.

Inventors: Mackay; Ian Reay (Malvern, AU), Rowley; Merrill Joy (Camberwell, AU), Zimmet; Paul Zev (Toorak, AU), Corner; Brian (St. Paul, MN), Law; Ruby (Caulfield, AU), Teoh; Khay-Lin (Singapore, SG)

Assignee: Montech Medical Developments Pty. Ltd.

International Classification: C12N 9/88 (20060101); A61K 38/00 (20060101); G01N 033/53 ()

Expiration Date: 12/26/2017