Patent Number: 6,165,747

Title: Nucleic acids encoding hedgehog proteins

Abstract: The present invention concerns the discovery that proteins encoded by a family of vertebrate genes, termed here hedgehog-related genes, comprise morphogenic signals produced by tissue patterning centers, and are involved in the formation of ordered spatial arrangements of differentiated tissues in vertebrates. The present invention makes available compositions and methods that can be utilized, for example to generate and/or maintain an array of different vertebrate tissue both in vitro and in vivo.

Inventors: Ingham; Philip W. (Summertown, GB), McMahon; Andrew P. (Lexington, MA), Tabin; Clifford J. (Cambridge, MA), Bumcrot; David A. (Belmont, MA), Marti-Gorostiza; Elisa (Brookline, MA)

Assignee: President & Fellows of Harvard College

International Classification: A01K 67/033 (20060101); A01K 67/00 (20060101); C07K 14/435 (20060101); C07K 14/46 (20060101); C07K 14/475 (20060101); C12N 15/85 (20060101); A61K 38/00 (20060101); C12N 015/12 (); C12N 015/10 (); C12N 005/00 (); C07K 014/475 ()

Expiration Date: 12/26/2017