Patent Number: 6,166,063

Title: N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV

Abstract: The present invention relates to a compound of formula (I) ##STR1## wherein R is substituted adamantyl; and n is 0 to 3; in free form or in acid addition salt form. Compounds of formula I inhibit DPP-IV (dipeptidyl-peptidase-IV) activity. They are therefore indicated for use as pharmaceuticals in inhibiting DPP-IV and in the treatment of conditions mediated by DPP-IV, such as non-insulin-dependent diabetes mellitus, arthritis, obesity, osteoporosis and further conditions of impaired glucose tolerance.

Inventors: Villhauer; Edwin Bernard (Morristown, NJ)

Assignee: Novartis AG

International Classification: C07D 207/00 (20060101); C07D 207/16 (20060101); A61K 031/401 (); A61P 005/48 (); C07D 207/12 (); C07D 207/14 ()

Expiration Date: 12/26/2017