Patent Number: 6,166,075

Title: Antiestrogens, process for their production and their pharmaceutical use

Abstract: This invention relates to new antiestrogens of the general formula ##STR1## in which the substituents have the meanings that are explained in more detail in the description.The new compounds are a) pure antiestrogens or b) antiestrogens with partial estrogenic action (tissue-selective estrogens).Based on these properties, the new compounds are suitable for the production of pharmaceutical agents: in the case of a), for example, for the treatment of breast cancer; in the case of b), for example, for hormone replacement therapy.

Inventors: Klar; Ulrich (Berlin, DE), Bohlmann; Rolf (Berlin, DE), Parczyk; Karsten (Berlin, DE), Fritzemeier; Karl-Heinrich (Berlin, DE), Lessl; Monika (Berlin, DE), Lichtner; Rosemarie (Berlin, DE)

Assignee: Schering Aktiengesellschaft

International Classification: C07C 217/00 (20060101); C07C 217/14 (20060101); C07C 317/00 (20060101); C07C 317/18 (20060101); C07C 323/12 (20060101); C07C 323/00 (20060101); C07D 303/22 (20060101); C07C 43/23 (20060101); C07D 303/00 (20060101); C07C 43/00 (20060101); A61K 031/22 (); A61K 031/045 (); A61K 031/075 (); A61K 031/10 (); C07D 303/00 ()

Expiration Date: 12/26/2013