Patent Number: 6,166,081

Title: Methods and apparatus for treatment of Parkinson's disease

Abstract: A pharmaceutical composition for treatment of Parkinson's disease comprising a compound of levodopa dissolved in a non-degradative solvent which allows transdermal administrtion of levodopa. The compound of levodopa is an alkyl-ester of levodopa and the solvent is a formulation comprising a substantially non-aqueous solvent, a transdermal enhancer and a detergent. The alkyl-ester of levodopa is preferably levodopa-ethyl-ester (LDEE).

Inventors: Kushnir; Moshe (Ramat Gan 52356, IL), Heldman; Eliahu (Rehovot 76516, IL)


International Classification: A61K 31/198 (20060101); A61K 31/185 (20060101); A61K 9/70 (20060101); A61K 31/195 (20060101); A61K 031/195 (); A61K 031/135 (); C07C 271/06 ()

Expiration Date: 12/26/2013