Patent Number: 6,166,082

Title: Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors

Abstract: Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formulawherein A and B are aryl or heteroaryl rings; each T is a substituent group; x is 0, 1, or 2; the group D represents ##STR1## the group E represents a three carbon chain bearing one to three substituent groups which are independent or are involved in ring formation, possible structures being shown in the text and claims; and the group G represents --M, ##STR2## in which M represents --CO.sub.2 H, --CON(R.sup.11).sub.2, or --CO.sub.2 R.sup.12 ; andR.sup.13 represents any of the side chains of the 19 noncyclic naturally occurring amino acids, and include pharmaceutically acceptable salts thereof.

Inventors: Kluender; Harold Clinton Eugene (Trumbull, CT), Benz; Guenter Hans Heinz Herbert (Velbert, DE), Brittelli; David Ross (Branford, CT), Bullock; William Harrison (Hamden, CT), Combs; Kerry Jeanne (Wallingford, CT), Dixon; Brian Richard (Woodbridge, CT), Schneider; Stephan (Wuppertal, DE), Wood; Jill Elizabeth (Hamden, CT), VanZandt; Michael Christopher (New Haven, CT), Wolanin; Donald John (Orange, CT), Wilhelm; Scott M. (Orange, CT)

Assignee: Bayer Corporation

International Classification: A61K 31/185 (20060101); A61K 31/192 (20060101); A61K 31/47 (20060101); A61K 31/403 (20060101); A61K 31/4035 (20060101); A61K 031/19 (); A61K 031/235 (); A61K 031/38 (); C07C 059/74 (); C07D 409/00 ()

Expiration Date: 12/26/2013