Patent Number: 6,166,089

Title: Prodrugs with enhanced penetration into cells

Abstract: The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to intracellular enzyme activity. The prodrug may be used in a technique for treating a condition or disease in a mammal related to supranormal intracellular enzyme activity, whereby on administering it to a human having such condition or disease, the bond is broken in response to such activity, and the pharmacologically active compound is activated selectively within cells having such supranormal intracellular enzyme activity.

Inventors: Kozak; Alexander (Rehovat, IL)

Assignee: D-Pharm, Ltd.

International Classification: A61K 31/352 (20060101); A01N 033/12 ()

Expiration Date: 12/26/2017