Patent Number: 6,166,130

Title: Method of using crosslinked polymer compositions in tissue treatment applications

Abstract: Crosslinked polymer compositions comprise a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (--NH.sub.2) or thiol (--SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer which contains, or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further comprise other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.

Inventors: Rhee; Woonza M. (Palo Alto, CA), DeLustro; Frank A. (Belmont, CA), Berg; Richard A. (Los Altos, CA)

Assignee: Cohesion Technologies, Inc.

International Classification: A61L 24/04 (20060101); A61L 27/00 (20060101); A61L 24/00 (20060101); A61L 27/26 (20060101); A61L 31/04 (20060101); C08G 65/00 (20060101); C08G 65/329 (20060101); C08L 71/00 (20060101); C08L 71/02 (20060101); C08F 283/00 (); C08G 063/91 (); C08G 063/48 ()

Expiration Date: 12/26/2017