Patent Number: 6,166,173

Title: Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same

Abstract: Biodegradable polymers are described comprising the recurring monomeric units shown in formula I or II: wherein X is --O-- or --NR'--, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms; M.sub.1 and M.sub.2 are each independently (1) a branched or straight chain aliphatic group having from 1-20 carbon atoms; or (2) a branched or straight chain, oxy-, carboxy- or amino-aliphatic group having from 1-20 carbon atoms; Y is --O--, --S-- or --NR'--, where R' is H or alkyl; R is H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; the molar ratio of x:y is about 1; the molar ratio n:(x or y) is between about 200:1 and 1:200; and the molar ratio q:r is between about 1:99 and 99:1; wherein said biodegradable polymer is biocompatible before and upon biodegradat.Processes for preparing the polymers, compositions containing the polymers and biologically active substances, articles useful for implantation or injection into the body fabricated from the compositions, and methods for controllably releasing biologically active substances using the polymers, are also described.

Inventors: Mao; Hai-Quan (Towson, MD), Leong; Kam W. (Ellicott City, MD), Zhao; Zhong (Baltimore, MD), English; James P. (Chelsea, AL)

Assignee: Guilford Pharmaceuticals Inc.

International Classification: A61L 17/00 (20060101); A61L 27/00 (20060101); A61L 27/18 (20060101); A61L 26/00 (20060101); C08G 63/692 (20060101); C08G 63/00 (20060101); C08G 63/91 (20060101); A61K 9/00 (20060101); A61K 9/16 (20060101); A61L 17/12 (20060101); C08G 079/04 (); A61K 031/80 ()

Expiration Date: 12/26/2013