Patent Number: 6,166,182

Title: Human neurotensin receptor type 2 and splice variants thereof

Abstract: Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

Inventors: Bergsma; Derk Jon (Berwyn, PA), Shabon; Usman (Swarthmore, PA)

Assignee: SmithKline Beecham Corporation

International Classification: C07K 14/435 (20060101); C07K 14/72 (20060101); A61K 48/00 (20060101); A61K 38/00 (20060101); A61K 39/00 (20060101); C07K 014/00 (); C07K 005/00 ()

Expiration Date: 12/26/2013