Patent Number: 6,166,184

Title: Process for making a bioprosthetic device

Abstract: Methods for making bioprosthetic devices made of collagen-based material having collagen amine groups and collagen carboxyl groups are provided. The methods include blocking at least a portion of the collagen amine groups with a blocking agent, activating at least a portion of the collagen carboxyl groups after blocking at least a portion of the collagen amine groups to form activated carboxyl groups, and contacting the activated collagen carboxyl groups with a polyfunctional spacer to crosslink the collagen-based material.

Inventors: Hendriks; Marc (Brunssum, NL), Michel; Verhoeven (Maastricht, NL), Cahalan; Patrick (Geleen, NL), Torrianni; Mark W. (San Juan Capistrano, CA), Cahalan; Linda (Geleen, NL), Fouache; Benedicte (Lille, FR)

Assignee: Medtronic Inc.

International Classification: A61L 27/00 (20060101); A61L 27/36 (20060101); C08H 1/06 (20060101); C08H 1/00 (20060101); C07K 013/00 (); C07K 015/00 ()

Expiration Date: 12/26/2013