Patent Number: 6,166,185

Title: Antibodies to human TIE-2 ligands

Abstract: The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.

Inventors: Davis; Samuel (New York, NY), Bruno; JoAnne (Bloomingdale, NJ), Goldfarb; Mitchell (River Edge, NJ), Aldrich; Thomas H. (Ossining, NY), Maisonpierre; Peter C. (Croton, NY), Radziejewski; Czeslaw (N. White Plains, NY), Jones; Pamela F. (Fairfield, CT), Yancopoulos; George D. (Yorktown Heights, NY)

Assignee: Regeneron Pharmaceuticals, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/515 (20060101); A61K 38/00 (20060101); C07K 016/18 (); C07K 016/22 (); C07K 016/24 ()

Expiration Date: 12/26/2017