Patent Number: 6,166,188

Title: Carbamate-derivatized nucleosides and oligonucleosides

Abstract: Nucleosides and oligonucleosides functionalized to include carbamate functionality, and derivatives thereof. In certain embodiments, the compounds of the invention further include steroids, reporter molecules, reporter enzymes, lipophilic molecules, peptides or proteins attached to the nucleosides through the carbamate group.

Inventors: Cook; Phillip Dan (Falbrook, CA), Manoharan; Muthiah (Carlsbad, CA)

Assignee: ISIS Pharmaceuticals, Inc.

International Classification: C07H 21/00 (20060101); C07H 19/00 (20060101); C07H 19/04 (20060101); C07G 011/00 (); C07H 019/00 (); C07H 021/00 (); C07H 021/02 (); C07H 021/04 ()

Expiration Date: 12/26/2013