Patent Number: 6,166,192

Title: PGC-1, a novel brown fat PPAR.gamma. coactivator

Abstract: The invention provides isolated nucleic acids molecules, designated PGC-1 nucleic acid molecules, which encode proteins which can modulate various adipocyte-associated activities including, for example, thermogenesis in adipocytes, e.g., brown adipocytes, and adipogenesis. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PGC-1 gene has been introduced or disrupted. The invention still further provides isolated PGC-1 proteins, fusion proteins, antigenic peptides and anti-PGC-1 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

Inventors: Spiegelman; Bruce M. (Waban, MA), Puigserver; Pere (Brookline, MA), Wu; Zhidan (Boston, MA)

Assignee: Dana-Farber Cancer Institute

International Classification: C07K 14/435 (20060101); C07K 14/575 (20060101); A61K 38/00 (20060101); C07H 021/04 ()

Expiration Date: 12/26/2017