Patent Number: 6,166,194

Title: TMPRSS2 is a tumor suppressor

Abstract: The present invention relates to the relation of the TMPRSS2 gene to human cancers and its use in the diagnosis and prognosis of human cancer. The invention also relates to the therapy of human cancers which have a mutation in the TMPRSS2 gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.

Inventors: Wong; Alexander K. C. (Salt Lake City, UT), Tavtigian; Sean V. (Salt Lake City, UT), Teng; David H. F. (Salt Lake City, UT)

Assignee: Myriad Genetics, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C07H 021/00 (); C07H 021/02 (); C07H 021/04 (); C12N 015/00 (); C12N 015/12 ()

Expiration Date: 12/26/2017