Patent Number: 6,166,201

Title: Process for the preparation of 1,4,7,10-tetraaza-cyclododecane-1,4,7-triacetic acid and the derivatives thereof

Abstract: A process for the preparation of 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid and the salts thereof of formula (I) ##STR1## which comprises the following steps: a) carboxymethylation reaction of a suitable precursor in water, with a haloacetic acid, b) hydrolysis reaction in basic conditions by addition of the base added at the previous step.

Inventors: Ripa; Giorgio (Milan, IT), Scala; Alessandro (Milan, IT), Murru; Marcella (Milan, IT), Panetta; Emanuela (Milan, IT), Viscardi; Carlo Felice (Milan, IT), Ausonio; Marina (Milan, IT)

Assignee: Dibra S.p.A.

International Classification: C07D 257/00 (20060101); C07D 257/02 (20060101); C07D 273/00 ()

Expiration Date: 12/26/2017