Patent Number: 6,166,203

Title: Heterocyclic amino substituted heteroaryl fused pyridines; GABA brain receptor ligands

Abstract: Disclosed are compounds of the formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: n is an integer from 0 to 3; the C ring is aryl or heteroaryl; X is CH, N, or O Z represents an electron pair, hydrogen, or (un)substituted heterocycle, aryl, or amido; W is (un)substituted alkyl, aryl, or heteroaryl; A and B are hydrogen or lower alkyl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

Inventors: Cai; Guolin (Guilford, CT), Liu; Gang (Agoura, CA), Chen; Guoquing (North Branford, CT), Albaugh; Pamela A. (Clinton, CT)

Assignee: Neurogen Corporation

International Classification: C07D 471/00 (20060101); C07D 495/00 (20060101); C07D 471/04 (20060101); C07D 495/04 (20060101); C07D 413/04 (); C07D 241/04 (); C07D 471/02 (); C07D 513/04 (); C07D 515/04 ()

Expiration Date: 12/26/2017