Patent Number: 6,166,205

Title: 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands

Abstract: Disclosed are compounds of the formula: ##STR1## or the pharmaceutically acceptable acid addition salts thereof wherein: R.sub.a represents ##STR2## where X, Y and Z are the same or different and represent CH or nitrogen;R.sub.1 R.sub.2, R.sub.3 and R.sub.4 independently represent organic or inorganic groups; andR.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl or halogen,which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.

Inventors: Chen; Xi (Clinton, CT), Thurkauf; Andrew (Danbury, CT)

Assignee: Neurogen Corporation

International Classification: C07D 401/12 (20060101); C07D 403/00 (20060101); C07D 401/00 (20060101); C07D 403/12 (20060101); C07D 401/14 (); C07D 403/14 ()

Expiration Date: 12/26/2013