Patent Number: 6,166,217

Title: Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril

Abstract: Process for the production of alkoxycarbonyldipeptides intermediates in the synthesis of the lisinopril which comprises protecting both amino functions of the L-lysine with an alkoxycarbonyl group, subsequently making the N-carboxyanhydride of the N6-[alkoxycarbonyl]-L-lysine by treatment with thionyl chloride and making the desired alkoxycarbonyldipeptide by reaction with L-proline in alkaline medium.

Inventors: Cannata; Vincenzo (Bologna, IT), Merli; Valeriano (Santa M. Maddalena, IT), Saguatti; Stefano (Bologna, IT)

Assignee: AlliedSignal Inc.

International Classification: C07K 1/00 (20060101); C07K 1/06 (20060101); C07K 1/08 (20060101); C07D 263/44 ()

Expiration Date: 12/26/2017