Patent Number: 6,166,226

Title: Synthesis of aryl ethers

Abstract: A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst selected from the group consisting of platinum and nickel to form an aryl ether. The aromatic compound comprises an activated substituent, X, said activated substituent being a moiety such that its conjugate acid HX has a pKa of less than 5.0. The catalyst is preferably a soluble palladium complex in the presence of supporting ligands.

Inventors: Buchwald; Stephen L. (Newton, MA), Wolfe; John P. (Brighton, MA), Palucki; Michael (Somerville, MA)

Assignee: Massachusetts Institute of Technology

International Classification: C07C 253/00 (20060101); C07C 41/00 (20060101); C07C 41/16 (20060101); C07C 253/30 (20060101); C07D 307/00 (20060101); C07D 307/79 (20060101); C07D 311/82 (20060101); C07D 313/00 (20060101); C07D 311/58 (20060101); C07D 309/12 (20060101); C07D 313/08 (20060101); C07D 311/00 (20060101); C07D 311/94 (20060101); C07D 309/00 (20060101); C07C 255/54 (20060101); C07C 255/00 (20060101); C07D 313/00 (); C07D 319/06 (); C07D 311/92 (); C07D 255/00 (); C07D 043/20 ()

Expiration Date: 12/26/2017