Patent Number: 6,166,227

Title: Preparation of (S)-2-amino-6, 6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

Abstract: The glycinamide of the formula (I) ##STR1## is reacted with the dioxolane of the formula (II) ##STR2## wherein L is a leaving group such as iodo, bromo, alkylsulfonyloxy, or arylsulfonyloxy to give the dioxolane of the formula (III) ##STR3## Treatment of (III) gives the dioxolane pentanoic acid IV ##STR4## which can be converted to (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester.

Inventors: Godfrey, Jr.; Jollie D. (Trenton, NJ), Kronenthal; David R. (Yardley, PA), Schwinden; Mark D. (Holland, PA)

Assignee: Bristol-Myers Squibb Co.

International Classification: C07C 229/22 (20060101); C07C 229/00 (20060101); C07D 317/00 (20060101); C07D 317/30 (20060101); C07D 317/00 ()

Expiration Date: 12/26/2017