Patent Number: 6,166,239

Title: Oligonucleotide protecting groups

Abstract: Compounds of the invention having general formula ##STR1## are useful reagents for protecting amine, guanidine, amidine or hydroxyl groups during organic synthesis. In particular, compounds are useful during oligonucleotide synthesis to protect nucleobase amines as well as tethered amines used for attaching functional moieties to oligonucleotides.

Inventors: Manoharan; Muthiah (Carlsbad, CA)

Assignee: Isis Pharmaceuticals, Inc.

International Classification: C07C 271/16 (20060101); C07C 271/00 (20060101); C07D 207/46 (20060101); C07C 279/00 (20060101); C07D 207/00 (20060101); C07C 279/24 (20060101); C07F 9/00 (20060101); C07F 9/24 (20060101); C07D 213/00 (20060101); C07D 213/64 (20060101); C07H 21/00 (20060101); C07C 069/96 (); C07C 277/00 ()

Expiration Date: 12/26/2013