Patent Number: 6,166,250

Title: Continuous hydrolysis process for the preparation of 2-hydroxy-4-methylthiobutanoic acid

Abstract: A continuous process for the preparation of 2-hydroxy-4-methylthiobutanoic acid which includes introducing sulfuric acid into a first reactor including a continuous stirred tank reactor and introducing 2-hydroxy-4-methylthiobutanenitrile into the first reactor. 2-hydroxy-4-methylthiobutanenitrile is continually hydrolyzed within the first reactor to produce an intermediate aqueous hydrolysis solution containing 2-hydroxy-4-methylthiobutanamide. The intermediate aqueous hydrolysis solution is continuously introduced into a plug flow reactor. 2-hydroxy-4-methylthiobutanamide is continually hydrolyzed within the plug flow reactor to produce an aqueous hydrolyzate product solution containing 2-hydroxy-4-methylthiobutanoic acid. 2-hydroxy-4-methylthiobutanoic acid is recovered from the aqueous hydrolyzate product solution.

Inventors: Hsu; Yung C. (Chesterfield, MO), Blackburn; Thomas F. (Chesterfield, MO), Pellegrin; Paul F. (St. Louis, MO), Kranz; Allen H. (St. Charles, MO), Willock; James M. (Ballwin, MO)

Assignee: Novus International, Inc.

International Classification: A23K 1/16 (20060101); B01J 19/18 (20060101); B01J 19/24 (20060101); B01J 14/00 (20060101); C07C 319/00 (20060101); C07C 319/20 (20060101); C07C 323/00 (20060101); C07C 323/52 (20060101); C07C 323/60 (20060101); C07C 051/42 (); C07C 381/00 ()

Expiration Date: 12/26/2017