Patent Number: 6,166,260

Title: Tandem reduction and host-guest complexation

Abstract: The present invention relates to a tandem process of reduction and host-guest complexation using metal-hydride complexes to reduce chemical entities bearing carbonyl groups or their equivalents, and host-guest complexation to achieve improved optical resolution of the reduction product. In the complexation step, the reduction product is optically resolved via inclusion into the crystalline complex where it resides as guest and another complex component acts as host. Additional crystallization stages are performed if further improvements in the enantiomeric excess is desired.

Inventors: Heise; Glenn L. (Nashua, NH)

Assignee: Zeeland Chemicals, Inc.

International Classification: C07C 213/00 (20060101); C07C 249/00 (20060101); C07C 249/02 (20060101); C07B 53/00 (20060101); C07C 29/00 (20060101); C07C 29/143 (20060101); C07B 57/00 (20060101); C07F 9/36 (20060101); C07F 9/00 (20060101); C07F 9/34 (20060101); C07C 215/00 (20060101); C07C 251/24 (20060101); C07C 251/00 (20060101); C07C 215/32 (20060101); C07C 029/143 (); C07C 029/136 (); C07C 029/78 (); C07C 029/92 ()

Expiration Date: 12/26/2017