Patent Number: 6,166,287

Title: Corticotropin-releasing factor overproducing transgenic mice

Abstract: In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as elevated plasma levels of ACTH and glucocorticoids. The transgenic mice of the present invention represent a genetic model of CRF overproduction, providing a valuable tool for investigating the long term effects of CRF excess and dysregulation in the central nervous system.

Inventors: Vale, Jr.; Wylie W. (La Jolla, CA), Stenzel-Poore; Mary P. (Westlinn, OR), Koob; George F. (Del Mar, CA), Heinrichs; Stephen C. (San Diego, CA)

Assignee: The Salk Institute for Biological Studies

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C12N 15/85 (20060101); C12N 015/09 (); C12N 015/63 (); C12N 015/00 ()

Expiration Date: 12/26/2017