Patent Number: 6,166,289

Title: IRAK modified transgenic animals

Abstract: A transgenic animal with alterations in an IRAK gene is prepared by introduction of an altered IRAK gene into a host animal. The resulting transgenic animals do not produce functional IRAK molecules. Cells and cell lines derived from these animals also contain the altered IRAK gene.

Inventors: Harris; Crafford A. (Easton, PA), Siekierka; John J. (Towaco, NJ), Peterson; Per A. (Bedminster, NJ), Leung; Wai-Ping (San Diego, CA)

Assignee: Ortho-McNeil Pharmacueticals

International Classification: C12N 15/85 (20060101); C12N 9/12 (20060101); A01K 067/027 (); C12N 015/00 ()

Expiration Date: 12/26/2017