Patent Number: 6,168,776

Title: Alkyl, alkenyl and alkynyl Chrysamine G derivatives for the antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition

Abstract: Amyloid binding compounds which are non-azo derivatives of Chrysamine G, pharmaceutical compositions containing, and methods using such compounds to identify Alzheimer's brain in vivo and to diagnose other pathological conditions characterized by amyloidosis, such as Down's Syndrome are described. Pharmaceutical compositions containing non-azo derivatives of Chrysamine G and methods using such compositions to prevent cell degeneration and amyloid-induced toxicity in amyloidosis associated conditions are also described. Methods using non-azo Chrysamine G derivatives to stain or detect amyloid deposits in biopsy or post-mortem tissue are also described. Methods using non-azo Chrysamine G derivatives to quantify amyloid deposits in homogenates of biopsy and post-mortem tissue are also described.

Inventors: Klunk; William E. (Pittsburgh, PA), Pettegrew; Jay W. (Pittsburgh, PA), Mathis, Jr.; Chester A. (Pittsburgh, PA)

Assignee: University of Pittsburgh

International Classification: C07C 65/00 (20060101); C07F 7/24 (20060101); C07C 65/03 (20060101); C07F 7/00 (20060101); A61K 049/02 (); C07C 062/33 (); C07C 065/03 (); C07F 007/24 ()

Expiration Date: 01/02/2018