Patent Number: 6,168,778

Title: Vascular endothelial growth factor (VEGF) Nucleic Acid Ligand Complexes

Abstract: This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Lipophilic Compound by identifying a VEGF Nucleic Acid Ligand by SELEX methodology and associating the VEGF Nucleic Acid Ligand with a Lipophilic Compound. The invention further discloses Complexes comprising one or more VEGF Nucleic Acid Ligands in association with a Lipophilic Compound. The invention further includes a Lipid construct comprising a VEGF Nucleic Acid Ligand or Complex and methods for making the same.

Inventors: Janjic; Nebojsa (Boulder, CO), Gold; Larry (Boulder, CO), Schmidt; Paul (Niwot, CO), Vargeese; Chandra (Thornton, CO)

Assignee: NeXstar Pharmaceuticals, Inc.

International Classification: C07H 21/00 (20060101); C07H 19/10 (20060101); C07K 14/00 (20060101); C07K 14/435 (20060101); C07H 19/00 (20060101); C07H 19/06 (20060101); C07K 14/52 (20060101); C07K 14/47 (20060101); C12Q 1/68 (20060101); C12Q 1/37 (20060101); C12N 15/11 (20060101); C12N 15/87 (20060101); C12Q 1/70 (20060101); C12N 9/12 (20060101); C12N 15/10 (20060101); C12N 15/88 (20060101); G01N 33/531 (20060101); G01N 33/532 (20060101); G01N 33/535 (20060101); G01N 33/68 (20060101); G01N 33/76 (20060101); G01N 33/569 (20060101); G01N 33/74 (20060101); A61K 38/00 (20060101); C07B 61/00 (20060101); F02B 75/02 (20060101); A61K 031/711 (); A61K 031/7105 (); C12Q 001/68 (); C12P 019/34 ()

Expiration Date: 01/02/2018