Patent Number: 6,168,779

Title: Methods and kits for identifying ductal orifices

Abstract: Methods, kits, and apparatus for locating, labelling, and accessing breast ducts are described. An orifice to one or more ductal networks is labelled using a specific binding substance, typically an antibody, specific for a tissue marker present on the orifice. Exemplary tissue markers include those present on the ductal epithelium, such as cytokeratins, including cytokeratin 8 and cytokeratin 18; E cadhedrin; and epithelial membrane antigen. Labelling of the ductal orifices permits reliable identification and access to each of the multiple ductal networks which may be present in an individual breast.

Inventors: Barsky; Sanford H. (Los Angeles, CA), Love; Susan M. (Pacific Palisades, CA)

Assignee: The Regents of the University of California

International Classification: A61K 49/00 (20060101); A61K 049/00 (); A61B 008/00 (); A61M 001/00 (); A61M 031/00 ()

Expiration Date: 01/02/2018