Patent Number: 6,168,783

Title: Antagonists of interleukin-15

Abstract: Antagonists of mammalian interleukin-15 ("IL-l5") are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R.alpha.-subunit and that are incapable of transducing a signal through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the .beta.- or .gamma.-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.

Inventors: Grabstein; Kenneth H. (Mercer Island, WA), Pettit; Dean K. (Seattle, WA), Paxton; Raymond J. (Bellevue, WA)

Assignee: Immunex Corporation

International Classification: C07K 14/435 (20060101); C07K 14/54 (20060101); C07K 16/24 (20060101); C07K 16/18 (20060101); A61K 38/00 (20060101); A61K 045/00 (); A61K 038/00 (); C07K 014/00 (); C07K 001/00 ()

Expiration Date: 01/02/2018