Patent Number: 6,168,784

Title: N-terminal modifications of RANTES and methods of use

Abstract: N-terminally modified RANTES derivatives are disclosed. The derivatives effectively block the inflammatory effects of RANTES, and are useful for the treatment of asthma, allergic rhinitis, atopic dermatitis, atheroma/atherosclerosis, and rheumatoid arthritis. Additionally, the compounds are useful for the treatment of HIV infection.

Inventors: Offord; Robin E. (Bernex, CH), Thompson; Darren (Santa Cruz, CA), Wilken; Jill (San Francisco, CA)

Assignee: Gryphon Sciences

International Classification: C07K 14/435 (20060101); C07K 14/52 (20060101); A61K 38/00 (20060101); A61K 038/19 (); C07K 014/52 ()

Expiration Date: 01/02/2018