Patent Number: 6,168,789

Title: Modified factor VII

Abstract: The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modifications render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders, including platelet deposition, vascular thrombosis, ischemic reperfusion, acute closure of a coronary artery, vascular restenosis secondary to balloon angioplasty, endarterectomy, reductive atherectomy, stent placement, laser therapy or rotablation.

Inventors: Berkner; Kathleen L. (Cleveland Heights, OH), Petersen; Lars Christian (Hoersholm, DK), Hart; Charles E. (Brier, WA), Hedner; Ulla (Malmo, SE), Bregengaard; Claus (Hellerup, DK)

Assignee: ZymoGenetics, Inc.

International Classification: A61K 38/43 (20060101); A61K 38/48 (20060101); A61K 038/48 (); A61K 035/14 (); C12N 009/48 (); C12N 009/64 ()

Expiration Date: 01/02/2018