Patent Number: 6,168,790

Title: Use of antibodies to block the effects of gram-positive bacteria and mycobacteria

Abstract: The present invention concerns a method of treating bacteremia, sepsis and other forms of toxemia caused by Gram-positive bacteria and mycobacteria comprising administering a therapeutically effective amount of anti-CD14 antibody molecules. A therapeutic composition comprising anti-CD14 antibody molecules in a pharmaceutically acceptable excipient is also contemplated.

Inventors: Ulevitch; Richard J. (Del Mar, CA), Tobias; Peter S. (San Diego, CA), Pugin; Jerome (Puplinge, CH)

Assignee: The Scripps Research Institute

International Classification: A61K 39/395 (20060101); C07K 16/28 (20060101); C07K 16/24 (20060101); C07K 16/18 (20060101); A61K 38/00 (20060101); A61K 039/40 ()

Expiration Date: 01/02/2018