Patent Number: 6,168,791

Title: Antibodies that bind immunomodulators

Abstract: This invention relates to a polypeptide other than human interleukin (10) which has at least one of the following properties: a) induces inhibition of spontaneous IL-8 production by human monocytes, b) induces inhibition of IL-1 beta induced IL-8 production by human peripheral blood mononuclear cells (PBMC), c) induces production of interleukin-1 receptor antagonistic protein (IRAP) by human monocytes, d) induces chemotactic migration of CD8+ human T lymphocytes in vitro, e) desensitizes human CDS+ T cells resulting in an unresponsiveness towards rhIL-10,f) suppresses the chemotactic response of CD4+ T human lymphocytes towards IL-8, g) suppresses the chemotactic response of human monocytes towards MCAF/MCP-1, h) induces the production of IL-4 by cultured normal human CD4+ T cells, i) reduces the TNF alpha production in human mixed leukocyte reaction. In particular, the invention relates to the nonapeptide Ala-Tyr-Met-Thr-Met-Lys-Ile-Arg-Asn (SEQ ID NO:1) and analogues and variants thereof.

Inventors: Larsen; Christian Gr.o slashed.nh.o slashed.j (Aarhus, DK), Gesser; Borbala (Hasselager, DK)

Assignee: Steeno Research Group A/S

International Classification: C07K 14/435 (20060101); C07K 14/54 (20060101); A61K 38/00 (20060101); A61K 39/00 (20060101); A61K 039/395 (); C07K 016/24 ()

Expiration Date: 01/02/2018