Patent Number: 6,168,801

Title: Controlled release drug delivery

Abstract: Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or dispersed therein at least two compounds having a common biologically active nucleus, but with different solubility parameters. The combination of the two different variants of the same drug with different solubility parameters provides the material with control over the rate of release of the compounds (by varying the proportions of the variants) and most importantly, extending the useful life of the device by enabling release of effective levels of the compounds over a longer period of time. The cylindrical carrier medium, comprised of silicone, further includes a tail, a skirt, or a rate-limiting membrane.

Inventors: Heil, Jr.; Ronald W. (Roseville, MN), KenKnight; Bruce H. (Maple Grove, MN)

Assignee: Cardiac Pacemakers, Inc.

International Classification: A61K 9/00 (20060101); A61F 002/02 ()

Expiration Date: 01/02/2018