Patent Number: 6,168,913

Title: Coding combinatorial libraries with fluorine tags

Abstract: The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching "tags" that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.

Inventors: Hochlowski; Jill Edie (Green Oaks, IL), Sowin; Thomas J. (Wadsworth, IL), Norbeck; Daniel W. (Crystal Lake, IL), Wade; Warren S. (Grayslake, IL), Whittern; David N. (Green Oaks, IL)

Assignee: Abbott Laboratories

International Classification: C07B 61/00 (20060101); C07K 1/04 (20060101); C07K 1/00 (20060101); C12Q 001/00 (); G01N 033/566 (); G01N 033/543 ()

Expiration Date: 01/02/2018