Patent Number: 6,168,926

Title: Protein inhibitor of neuronal nitric oxide synthase

Abstract: An nNOS associated protein designated PIN-1 (Protein Inhibitor of nNOS) has been identified. It physically interacts with nNOS and inhibits its activity. Multiple lines of evidence indicate that PIN-1 is a regulator of nNOS: it is physiologically associated with nNOS, and it inhibits its catalytic activity. The extraordinary evolutionary conservation of PIN-1 and preliminary evidence that it interacts with multiple proteins, suggests that it may be a major biological regulatory protein influencing numerous physiological processes.

Inventors: Snyder; Solomon H. (Baltimore, MD), Jaffrey; Samie R. (Baltimore, MD)

Assignee: The Johns Hopkins University

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C12Q 1/26 (20060101); G01N 033/53 (); G01N 033/567 (); C22Q 001/00 (); C12Q 001/68 (); C12P 001/00 ()

Expiration Date: 01/02/2018